Designed to provide research funding for single or multiple investigators to address critical gaps and challenges and potential breakthroughs in Type 1 diabetes research
Domestic & foreign non-profit organizations; public & private universities, colleges, hospitals, laboratories; units of state & local governments; eligible agencies of the federal government
Required: MD, DMD, DVM, PhD, or equivalent and faculty position or equivalent
Human Subjects Research
For a project proposing Human Subject Research, please review the Human Subject Research Guidelines
Please see the Submitting an Application section below for project concept deadlines
JDRF’s Strategic Research Agreements provide research funding for single or multiple investigators to address critical gaps and challenges and potential breakthroughs in Type 1 diabetes research. The Strategic Research Agreement is a partnership between Investigator(s) and JDRF Scientists to help address roadblocks and accelerate JDRF’s mission through support of cutting-edge scientific investigation. Further, this mechanism embodies cooperative development of a research plan, interim quarterly reporting on milestones and interaction with JDRF scientists prior to and during the award period. The budget and duration of funding are variable and continued funding is based on satisfactory effort and quarterly progress on milestones. Submission of an application requires permission from JDRF and is initiated with a Project Concept submitted to the JDRF Project Concept Call in RMS360
Successful Project Concept applicants will be contacted for further project development by JDRF personnel.
Applicants must hold an MD, DMD, DVM, PhD, or equivalent and have a faculty position or equivalent at a college, university, medical school, company, or other research facility. Applications may be submitted by domestic and foreign non-profit organizations, public and private, such as colleges, universities, hospitals, laboratories, units of state and local governments, and eligible agencies of the federal government. Ordinarily, for-profit organizations will not be considered, except under special circumstances. See the Industry Discovery & Development Partnerships section for a description of special programs for for-profit entities. There are no citizenship requirements for this program. To assure continued excellence and diversity among applicants and awardees, JDRF welcomes applications from all qualified individuals and encourages applications from persons with disabilities, women, and members of minority groups underrepresented in the sciences.
Step 1: Project Concept
An investigator interested in pursuing a research opportunity with JDRF must submit a Project Concept through JDRF’s Project Concept Call in RMS360. Project Concepts are selected on the basis of programmatic fit and robustness of the concept. In addition, projects that hold a prospect for transformative breakthroughs that prevent, treat or cure Type 1 diabetes will be given top priority.
Project concepts are due at 5 PM ET on the deadline date. No extensions will be granted.
To view upcoming deadlines, click here.
Step 2: Full Application
If the applicant’s Project Concept is approved by JDRF, the applicant will be invited to submit a full research application. The applicant will be authorized to access and electronically submit the completed application via RMS360.
Note: For a project proposing Human Subject Research, please review the Human Subject Research Guidelines.
Available funding for the Strategic Research Agreement will be reviewed on a per-application basis. Projects will be milestone-driven, require teleconferences with the Scientific Staff to discuss project progress and research findings on a quarterly basis. In addition to quarterly reports, an annual progress report will be due 2 months prior to the anniversary date of the award, except in the final year, in which the progress report is due 75 days following the close of the award. Projects are no more than 3 years duration. Support beyond 3 years will be determined based on a detailed scientific review of the accomplishments and future plans of the Project. Decisions on continued funding are made by the Program Director in consultation with Senior Management based on progress on milestones. Indirect costs cannot exceed 10% of direct costs (direct costs do not include equipment costs, fee-for-services, consultants, or subcontract costs).
The JDRF Strategic Research Agreement for multiple projects provides a mechanism to stimulate new collaborations between clinical and basic scientists and/or between scientists from diverse backgrounds as a means to conceive and develop new approaches to major challenges, potential breakthroughs, or persistent obstacles to progress along the various paths to prevent, treat or cure Type 1 diabetes and its complications.
A central theme highly relevant to the priority areas of research for JDRF is required and must include a set of clearly defined goals that can be met within a 3-year period. In most cases, Multi-Project SRAs will focus on basic or pre-clinical research that seeks to impact the treatment or prevention of Type 1 diabetes and its complications. However, clinical studies meeting the other criteria for Multi-Project SRAs will be considered. Multi-Project SRAs may be composed of 3-6 projects and 1-3 cores, with component projects being highly interactive and benefiting from the use of common cores. In general, the component projects will have interdependent outcomes. An overall Project Principal Investigator is required. Generally, administration of the Project will rely on mutually agreed-upon leadership and common consent of the individual project principal investigators. In many instances, an administrative core will not be necessary, and any budget requests for administrative support must be strongly justified in the Multi-Project SRA application.
Upon approval of the Project Concept, the Multi-Project SRA overview application will become available. The Principal Investigators of Individual Projects & Cores must complete separate online applications on RMS360 for each Multi-Project SRA Individual Project/Core. JDRF Staff will make the Multi-Project SRA Individual Project/Core application templates available to the PI of each Individual Project/Core.
The titles for each Individual Project/Core application MUST begin with the last name of the Multi-Project SRA Director (even if some Projects and Cores have different PIs) followed by its component. For example:
Each Individual Project/Core should complete and submit its own budget within its individual application, and all Individual Project/Core budgets should be entered into the Composite Budget within the Overview Application for each year. Within the Composite Budget of the Overview Application, click the Add Project/Core button to enter subtotals for each Project/Core for each year. Please contact the appropriate JDRF Pre-Award Staff for more information on completing the Composite and each Individual Project/Core Budget.
The overall application and each individual project/core will be evaluated by the review committee. Reviewers will be asked to: 1) assess each project on its own merits; and 2) assess each project as part of the overall Project and whether it should be included. Reviewers will be provided with the full application to assist them in their evaluation. As with the Single-Project, reviewer comments will be shared with the Investigator team and given an opportunity to respond to the commentary.
The relationship and contributions of each individual research project and core to the overall theme of the Multi-Project SRA application will be evaluated by the review committee and scored using the JDRF scoring guide. Assessment of the overall application is conducted after all individual research projects have been reviewed and rated. Reviews will be performed by an appropriate review group. The following criteria are among those which will be considered by the review committee:
JDRF Clinical SRAs are are intended to support research programs that qualify under the JDRF clinical review process. This funding mechanism is intended to support early-stage clinical trials to test therapeutic approaches as well as non-interventional patient oriented studies that are intended to lead to the development of clinical interventions and monitoring tools (such as markers) for diabetes and its complications. Applications for Strategic Research Agreement – Clinical must be goal oriented and closely focused on the JDRF mission.
All applications involving human subject research must include supplemental information to address subject safety, study design and investigational product information. More details can be found in the Human Subject Research Guidelines. All applications that receive a funding recommendation after scientific review will undergo clinical review where a subsequent review of the study protocol and supporting documents will be performed.
The Steering Committee of the T1D Outcomes Program has defined the following outcomes: hypoglycemia, hyperglycemia, time-in-range, and diabetic ketoacidosis (DKA). JDRF requires that all newly funded clinical studies incorporate the appropriate outcomes. Further, outcomes incorporated into a study should be consistent with the definitions from the publication, and we recommend their usage as endpoints in all T1D studies. Protocols that include measurement of these outcomes that are not defined per the publication must provide justification prior to grant approval. Please see relevant resources- fact sheet and video.
Clinical SRAs will be – Clinical will be evaluated for scientific merit, clinical standards of care for the proposed patient population and adherence to Good Clinical Practice. The scientific review criteria include:
The mission of this group at JDRF is to facilitate execution of high quality clinical trials. Please click the link for the current Human Subject Research Guidelines with a few additions as listed below.
Please speak with your proposal/study assigned JDRF-CTM if you have any questions or need clarifications.